Symbol Name ID |
Ptpn11
protein tyrosine phosphatase, non-receptor type 11 MGI:99511 |
Darker colors indicate more annotations |
Human Phenotypes | Delayed menarche |
Hypogonadism |
Hypogonadotropic hypogonadism |
Abnormality of the genital system |
Hypospadias |
Micropenis |
Cryptorchidism |
Aplasia of the ovary |
Hypoplasia of the ovary |
Male infertility |
Disease(s) Associated with PTPN11 | ||||||||||
Noonan syndrome | ||||||||||
Noonan syndrome 1 | ||||||||||
Noonan syndrome with multiple lentigines 1 |
Mouse Phenotypes | azoospermia |
abnormal spermatocyte morphology |
abnormal spermatogonia morphology |
decreased male germ cell number |
increased male germ cell apoptosis |
abnormal seminiferous tubule epithelium morphology |
abnormal Sertoli cell barrier morphology |
small seminiferous tubules |
seminiferous tubule degeneration |
increased Leydig cell number |
decreased testis weight |
small testis |
abnormal Sertoli cell barrier function |
abnormal reproductive system morphology |
arrest of spermatogenesis |
impaired embryo implantation |
reduced female fertility |
decreased litter size |
male infertility |
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Availability | Mouse Genotype | |||||||||||||||||||
Ptpn11tm1Rbn/Ptpn11tm1Rbn | ||||||||||||||||||||
Ptpn11tm5Bgn/Ptpn11tm5Bgn | ||||||||||||||||||||
Ptpn11tm4.2Bgn/Ptpn11+ | ||||||||||||||||||||
Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Camk2a-cre)2Szi/0 (conditional) |
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Ptpn11tm1Gsf/Ptpn11tm1Gsf Plekha5Tg(AMH-cre)1Flor/Plekha5+ (conditional) |
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Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Inha-cre)3Zuk/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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