Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to reproductive system

Darker colors indicate more annotations

Human Phenotypes	Delayed menarche	Hypogonadism	Hypogonadotropic hypogonadism	Abnormality of the genital system	Hypospadias	Micropenis	Cryptorchidism	Aplasia of the ovary	Hypoplasia of the ovary	Male infertility
Disease(s) Associated with PTPN11	Delayed menarche	Hypogonadism	Hypogonadotropic hypogonadism	Abnormality of the genital system	Hypospadias	Micropenis	Cryptorchidism	Aplasia of the ovary	Hypoplasia of the ovary	Male infertility
Noonan syndrome
Noonan syndrome 1
Noonan syndrome with multiple lentigines 1

Mouse Phenotypes

azoospermia

abnormal spermatocyte morphology

abnormal spermatogonia morphology

decreased male germ cell number

increased male germ cell apoptosis

abnormal seminiferous tubule epithelium morphology

abnormal Sertoli cell barrier morphology

small seminiferous tubules

seminiferous tubule degeneration

increased Leydig cell number

decreased testis weight

small testis

abnormal Sertoli cell barrier function

abnormal reproductive system morphology

arrest of spermatogenesis

impaired embryo implantation

reduced female fertility

decreased litter size

male infertility

Availability

Mouse Genotype

Ptpn11^tm1Rbn/Ptpn11^tm1Rbn

Ptpn11^tm5Bgn/Ptpn11^tm5Bgn

Ptpn11^tm4.2Bgn/Ptpn11⁺

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Camk2a-cre)2Szi/0 (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Inha-cre)3Zuk/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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